EFFICACY OF INTRAVENOUS IMMUNOGLOBULINS IN RH INCOMPATIBLE NEONATES

Authors

  • IZHAR MUHAMMAD Institute of Kidney Diseases Peshawar.
  • HUSNA KHAN Combined Military Hospital Rawalpindi
  • SANA PERVEZ Khyber Teaching hospital peshawar
  • TANVEER AHMAD Khyber Teaching hospital peshawar

DOI:

https://doi.org/10.33279/jkcd.v13i2.27

Abstract

BACKGROUND

This hemolytic disease of fetus and newborn is a condition in which there is immunologic hemolysis of fetal / neonatal red blood cells.

OBJECTIVE: 

To compare the efficacy of intravenous immunoglobulins in reducing the need for exchange transfusion in Rh incompatible neonates.

MATERIALS AND METHOD: 

This Randomized Controlled Trial was conducted from 1st September 2021 to 31st August 2022 at Department of Pediatric Medicine, Khyber Teaching Hospital, Peshawar. A total of 92 Rh incompatible neonates having bilirubin more than 8mg/dl  were included in the study. Randomization was performed through lottery method. All neonates received conventional intensive phototherapy given by air shield and Ohmeda lamps with  white light  having an intensity of 22 μW/cm/nm plus  blue light of 32 μW/cm/nm. Extra fluids (10 mL per kg) was administered during the phototherapy session. Subjects  in group A  received  conventional intensive phototherapy and IVIG single dose(1 gm/kg). In group B saline was given instead of IVIG. A change in bilirubin of 1mg was considered effective after 4 hours of starting treatment. Data was recorded for efficacy.

RESULTS:

Mean age of  Group A was  15.369± 4.98 days in Group A while 17.782± 3.31 days in Group B. Mean gestational age at birth was 37.608±1.58 weeks in Group A and 38.173±1.71 weeks in Group B. Mean parity was 3.534±0.28 in Group A and 3.387±0.36 in Group B. Mean hospital stay in group A was 3.2±1.5days while 5.7±1.2 days in group B.  In group A, efficacy was seen in 38 (82.6%) patients as compare to 26 (56.5%) patients in group B, resulting in significant reduction of exchange transfusions, duration of phototherapy session and hospital stay (P=0.006).

CONCLUSION: 

          It is concluded that a IVIG administration in patients having significant  hyperbilirubinemia of Rh incompatible neonates caused reduction in requirement for exchange transfusion ,decreased hospital and time duration of phototherapy treatment thus an effective and safe treatment

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Published

2023-06-30

How to Cite

MUHAMMAD, I., HUSNA KHAN, SANA PERVEZ, & TANVEER AHMAD. (2023). EFFICACY OF INTRAVENOUS IMMUNOGLOBULINS IN RH INCOMPATIBLE NEONATES. JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 13(2), 2–5. https://doi.org/10.33279/jkcd.v13i2.27

Issue

Vol. 13 No. 2 (2023): Journal of Khyber College of Dentistry

Section

Original Article

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Copyright (c) 2023 IZHAR MUHAMMAD, HUSNA KHAN, SANA PERVEZ, TANVEER AHMAD

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